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. 2010 Nov 30;5(11):e14131. doi: 10.1371/journal.pone.0014131

Figure 6. A17 signature under-expression predicts response to neoadjuvant therapy.

Figure 6

Module map analysis on a cohort of samples completely (pCR) or not completely (npCR) sensitive to neoadjuvant therapy demonstrated that A17 signatures are under-expressed in pCR samples (a). Hierarchical clusterization of the dataset filtered for the most differentially expressed genes (SD>1.5) generated two major clusters, one of which exhibited features of Basal-like tumors (b: yellow frame). The basal-like cluster included a higher percentage of npCR samples than the other cluster.