Table 1. Clinical and laboratory characteristics of study patients with A. baumannii bacteremia.
| Characteristicsa | Total (n = 51) | Nonsurvivor group (n = 34) | Survivor group (n = 17) | P |
| Age | 61.5 (48.9–74.2) | 59.9 (48.0–74.6) | 61.5 (49.0–71.7) | 0.84 |
| Sex, M/F | 33/18 | 22/12 | 11/6 | 1.00 |
| Days of prior hospitalizationb | 18 (10–41) | 19.5 (10–47.3) | 18 (10–29.5) | 0.75 |
| Days of prior ICU stayb | 10 (0–18) | 10 (0.8–16.3) | 14 (0–18) | 0.80 |
| APACHE II score, ICU admission | 26 (20.5–36) | 27 (20.5–36) | 25.5 (20.3–35) | 0.73 |
| Underlying illness | ||||
| Charlson score | 3 (2–6) | 3 (2–6) | 4 (2–6) | 0.91 |
| Diabetes mellitus | 20 (39.2) | 11 (32.4) | 9 (52.9) | 0.23 |
| Congestive heart failure | 7 (13.7) | 5 (14.7) | 2 (11.8) | 1.00 |
| Chronic renal insufficiency | 16 (31.4) | 11 (32.4) | 5 (29.4) | 1.00 |
| Immunosuppressantsc | 22 (43.1) | 18 (52.9) | 4 (23.5) | 0.07 |
| Leukemia | 7 (13.7) | 7 (20.6) | 0 (0) | 0.08 |
| Lymphoma | 3 (5.9) | 2 (5.9) | 1 (5.9) | 1.00 |
| Focus of infection | ||||
| Primary bacteremia | 11 (21.6) | 7 (20.6) | 4 (23.5) | 1.00 |
| Pneumonia | 33 (64.7) | 24 (70.6) | 9 (52.9) | 0.23 |
| Intra-abdominal infection | 4 (7.8) | 2 (5.9) | 2 (11.8) | 0.59 |
| Surgical site infection | 4 (7.8) | 4 (11.8) | 0 (0) | 0.29 |
| Laboratory data on day 0b | ||||
| White blood cell count (1000/µL) | 10.29 (2.42–20.34) | 8.36 (0.55–20.64) | 12.07 (8.50–19.97) | 0.19 |
| Hemoglobin (g/dL) | 9.4 (8.5–10.4) | 9.2 (8.2–10.5) | 9.6 (8.9–10.7) | 0.35 |
| Platelet count (1000/µL) | 73 (41–134) | 56 (19–96.8) | 134 (74–275.5) | <0.001 |
| ASTd (U/L) | 50 (25–95) | 67 (30–117) | 35 (17.5–58.3) | 0.15 |
| Total bilirubin (mg/dL) | 2.56 (0.83–9.06) | 3 (0.8–25.5) | 1.9 (0.7–3.3) | 0.32 |
| Creatinine (mg/dL) | 1.8 (1.1–3.2) | 1.9 (1.1–3.8) | 1.7 (1.1–3) | 0.81 |
| C-reactive protein (mg/dL) | 9.6 (4.6–16.4) | 9.8 (5.3–21.1) | 8.7 (2.3–12.7) | 0.37 |
a
Data are median (interquartile range) for continuous variables and number of cases (percentage) for categorical variables, with two-tailed Mann-Whitney U test for the former and Fisher's exact test for the later.
b
Days of hospitalization and ICU stay prior to day 0, which was the day on which the first blood sample positive for A. baumannii by culture was drawn.
c
Immunosuppressants included antineoplastic therapy within 6 weeks of the onset of A. baumannii bacteremia, corticosteroids at a dose ≧ 20 mg of prednisolone daily for at least 2 weeks or 30 mg of prednisolone daily for at least 1 week before a positive blood culture for A. baumannii, and other immunosuppressants such as cyclophosphamide [15].
d
AST: aspartate aminotransferase.