Table 5. Validation of the thresholds for HLA-class I histocompatibility and the tolerance induction from Table 4.

Factor	Hazards ratio	p-value
Tolerogenic factor higher than 220 eplets2	2.00	<0.01
More than 10 HLAMatchmaker eplets at HLA-A/-B	1.50	0.02
Risk estimation at time of keratoplasty (low versus high risk)	0.56	<0.01

This Cox model is fitted to cohort 2 comprising of 975 consecutive patients. The model is adjusted for low- versus high-risk keratoplasties. Immune reactions were the only endpoint.