Table 4. Association of common hapltoypes (>1% frequency).
|
|
Full sample (over-all p-value=0.156) |
Restricted sample (over-all p-value=0.140) |
||||||
|---|---|---|---|---|---|---|---|---|
| Haplotype | f cases | f controls | p-value | OR (95%CI) | f cases | f controls | p-value | OR (95%CI) |
| ATAGCCC |
0.19 |
0.18 |
0.536 |
1.06 (0.89–1.25) |
0.20 |
0.18 |
0.305 |
1.13 (0.89–1.44) |
| ATAACTT |
0.28 |
0.27 |
0.452 |
1.06 (0.91–1.23) |
0.28 |
0.26 |
0.304 |
1.12 (0.90–1.39) |
| TTAAGTC |
0.23 |
0.22 |
0.303 |
1.00 (0.93–1.28) |
0.23 |
0.23 |
0.733 |
1.04 (0.83–1.30) |
| AGCAGCC |
0.16 |
0.18 |
0.037 |
0.83 (0.69–0.90) |
0.13 |
0.19 |
0.004* |
0.68 (0.52–0.89) |
| TTAAGCC |
0.02 |
0.01 |
0.256 |
1.09 (0.93–1.28) |
0.01 |
0.01 |
0.617 |
1.26 (0.50–3.17) |
| AGCAGTC |
0.05 |
0.04 |
0.441 |
1.14 (0.82–1.57) |
0.05 |
0.04 |
0.351 |
1.23 (0.90–1.91) |
| ATAACCC | 0.08 | 0.09 | 0.115 | 0.82 (0.64–1.05) | 0.08 | 0.09 | 0.811 | 0.96 (0.68–1.36) |
Results are presented for the full sample and the sample restricted to severe cases and elderly controls. All p-values and odds ratios (OR) are shown for the specific haplotype versus all other hapltoypes. Nominally significant values are in bold. The asterisk indicates survives Bonferonni correction for 7 observed haplotypes tested.