Table 1. Effect of GABA on fetal body and lung weights during fetal lung development.
Condition | Fetal body weight (% Control) | Fetal Lung weight (% Control) | LW/BW (% of Control) |
PBS | 100.00±1.28 | 100.00±2.17 | 100.00±1.47 |
GABA | 105.34±1.31* | 118.26±2.86* | 112.36±2.39* |
Bicuculline | 97.66±1.46 | 96.66±2.49 | 99.06±2.20 |
GABA+Bicuculline | 101.43±2.14# | 100.92±3.92# | 99.15±2.79# |
The fetal body weights (BW) in uninjected animals were 4.37±0.10 grams whereas those injected with PBS were 4.55±0.11 grams. Fetal lung weights (LW) in the uninjected and PBS treatment were 131.23±7.05 mg and 136.69±4.36 mg, respectively. The LW/BW (expressed as a percent) in PBS-injected fetuses was 3.02±0.06. Values represent means±SEM from 11–35 fetuses isolated from 4–13 rats. All the values were expressed as percents of PBS control.
*p<0.05 v.s. PBS;
p<0.05 v.s. GABA.