Table 1. Distribution of demographic and behavioral risk factors for advanced age-related macular degeneration and controls according to hepatic lipase-C (LIPC) genotypes.
|
|
Controls |
Geographic atrophy |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CC |
CT |
TT |
|
CC |
CT |
TT |
|
||||||
| LIPC: rs10468017 Genotype | N | % | N | % | N | % | p value* | N | % | N | % | N | % | p value* |
|
Baseline age | ||||||||||||||
| 50-69 |
89 |
(70) |
92 |
(76) |
21 |
(81) |
|
38 |
(46) |
28 |
(56) |
4 |
(57) |
|
| 70-95 |
39 |
(30) |
29 |
(24) |
5 |
(19) |
0.30 |
44 |
(54) |
22 |
(44) |
3 |
(43) |
0.57 |
|
Gender | ||||||||||||||
| Male |
58 |
(45) |
57 |
(47) |
10 |
(38) |
|
44 |
(54) |
24 |
(48) |
3 |
(43) |
|
| Female |
70 |
(55) |
64 |
(53) |
16 |
(62) |
0.49 |
38 |
(46) |
26 |
(52) |
4 |
(57) |
0.58 |
|
Education | ||||||||||||||
| High School or Less |
7 |
(5) |
4 |
(3) |
1 |
(4) |
|
7 |
(9) |
6 |
(12) |
0 |
0.0 |
|
| College or more |
121 |
(95) |
117 |
(97) |
25 |
(96) |
0.80 |
75 |
(91) |
44 |
(88) |
7 |
100.0 |
0.47 |
|
Smoking | ||||||||||||||
| Never |
67 |
(52) |
56 |
(46) |
15 |
(58) |
|
30 |
(37) |
16 |
(32) |
3 |
(43) |
|
| Former |
58 |
(45) |
57 |
(47) |
10 |
(38) |
0.50 |
42 |
(51) |
31 |
(62) |
3 |
(43) |
0.71 |
| Current |
3 |
(2) |
8 |
(7) |
1 |
(4) |
0.99 |
10 |
(12) |
3 |
(6) |
1 |
(14) |
1.00 |
|
BMI | ||||||||||||||
| <25.0 |
39 |
(30) |
40 |
(33) |
9 |
(35) |
|
23 |
(28) |
16 |
(32) |
3 |
(43) |
|
| 25.0-29.9 |
55 |
(43) |
59 |
(49) |
13 |
(50) |
0.98 |
35 |
(43) |
20 |
(40) |
1 |
(14) |
0.17 |
| ≥ 30.0 |
34 |
(27) |
22 |
(18) |
4 |
(15) |
0.35 |
24 |
(29) |
14 |
(28) |
3 |
(43) |
0.97 |
| P for Trend |
|
|
|
|
|
|
0.40 |
|
|
|
|
|
|
0.97 |
|
Supplements | ||||||||||||||
| No Antioxidants |
69 |
(54) |
66 |
(55) |
17 |
(65) |
|
44 |
(54) |
30 |
(60) |
4 |
(57) |
|
| Antioxidants |
59 |
(46) |
55 |
(45) |
9 |
(35) |
0.28 |
38 |
(46) |
20 |
(40) |
3 |
(43) |
0.84 |
|
Lutein: Calorie Adjusted, Sex specific (mean µg) | ||||||||||||||
| Males |
|
1543.1 |
|
1703.1 |
|
1520.6 |
0.55 |
|
1329.5 |
|
1549.6 |
|
1100.7 |
0.67 |
| Females |
|
1468.0 |
|
1374.1 |
|
1607.8 |
0.91 |
|
1221.2 |
|
1361.6 |
|
1193.4 |
0.65 |
|
|
Neovascular disease |
Combined advanced AMD |
||||||||||||
|
|
CC |
CT |
TT |
|
CC |
CT |
TT |
|
||||||
|
LIPC: rs10468017 Genotype |
N |
% |
N |
% |
N |
% |
p value* |
N |
% |
N |
% |
N |
% |
p value* |
|
Baseline Age | ||||||||||||||
| 50-69 |
102 |
(48) |
89 |
(51) |
4 |
(19) |
|
140 |
(48) |
117 |
(52) |
8 |
(29) |
|
| 70-95 |
109 |
(52) |
85 |
(49) |
17 |
(81) |
0.01 |
153 |
(52) |
107 |
(48) |
20 |
(71) |
0.05 |
|
Gender | ||||||||||||||
| Male |
88 |
(42) |
64 |
(37) |
6 |
(29) |
|
132 |
(45) |
88 |
(39) |
9 |
(32) |
|
| Female |
123 |
(58) |
110 |
(63) |
15 |
(71) |
0.24 |
161 |
(55) |
136 |
(61) |
19 |
(68) |
0.18 |
|
Education | ||||||||||||||
| High School or Less |
32 |
(15) |
11 |
(6) |
5 |
(24) |
|
39 |
(13) |
17 |
(8) |
5 |
(18) |
|
| College or more |
179 |
(85) |
163 |
(94) |
16 |
(76) |
0.24 |
254 |
(87) |
207 |
(92) |
23 |
(82) |
0.48 |
|
Smoking | ||||||||||||||
| Never |
78 |
(37) |
70 |
(40) |
11 |
(52) |
|
108 |
(37) |
86 |
(38) |
14 |
(50) |
|
| Former |
108 |
(51) |
82 |
(47) |
8 |
(38) |
0.18 |
150 |
(51) |
113 |
(50) |
11 |
(39) |
0.17 |
| Current |
25 |
(12) |
22 |
(13) |
2 |
(10) |
0.48 |
35 |
(12) |
25 |
(11) |
3 |
(11) |
0.53 |
|
BMI | ||||||||||||||
| <25.0 |
45 |
(21) |
51 |
(29) |
4 |
(19) |
|
68 |
(23) |
67 |
(30) |
7 |
(25) |
|
| 25.0-29.9 |
100 |
(47) |
74 |
(43) |
10 |
(48) |
0.86 |
135 |
(46) |
94 |
(42) |
11 |
(39) |
0.63 |
| ≥ 30.0 |
66 |
(31) |
49 |
(28) |
7 |
(33) |
0.79 |
90 |
(31) |
63 |
(28) |
10 |
(36) |
0.87 |
| p for Trend |
|
|
|
|
|
|
0.80 |
|
|
|
|
|
|
0.84 |
|
Supplements | ||||||||||||||
| No Antioxidants |
109 |
(52) |
84 |
(48) |
8 |
(38) |
|
153 |
(52) |
114 |
(51) |
12 |
(43) |
|
| Antioxidants |
102 |
(48) |
90 |
(52) |
13 |
(62) |
0.24 |
140 |
(48) |
110 |
(49) |
16 |
(57) |
0.34 |
|
Lutein: Calorie Adjusted, Sex specific (mean µg) | ||||||||||||||
| Males |
|
1430.4 |
|
1651.6 |
|
1295.3 |
0.28 |
|
1395.9 |
|
1623.1 |
|
1226.9 |
0.25 |
| Females | 1254.8 | 1203.0 | 1315.6 | 0.86 | 1246.8 | 1231.8 | 1288.9 | 0.98 | ||||||
*p value indicates the relationship between the number of T alleles for LIPC and each category of the variable.