Table 2. Associations between hepatic lipase-C (LIPC) genotypes and ather AMD related genetic variants.
|
|
Controls |
Geographic atrophy |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CC |
CT |
TT |
|
CC |
CT |
TT |
|
||||||
| LIPC: rs10468017 Genotype | N | % | N | % | N | % | p value* | N | % | N | % | N | % | p value* |
|
CFH: rs1061170 (Y402H) | ||||||||||||||
| TT |
42 |
(33) |
57 |
(47) |
14 |
(54) |
|
14 |
(17) |
8 |
(16) |
1 |
(14) |
|
| CT |
67 |
(52) |
48 |
(40) |
8 |
(31) |
|
32 |
(39) |
20 |
(40) |
3 |
(43) |
|
| CC |
19 |
(15) |
16 |
(13) |
4 |
(15) |
0.096 |
36 |
(44) |
22 |
(44) |
3 |
(43) |
0.86 |
|
CFH: rs1410996 | ||||||||||||||
| TT |
16 |
(13) |
25 |
(21) |
6 |
(23) |
|
1 |
(1) |
2 |
(4) |
1 |
(14) |
|
| CT |
65 |
(51) |
64 |
(53) |
14 |
(54) |
|
27 |
(33) |
11 |
(22) |
3 |
(43) |
|
| CC |
47 |
(37) |
32 |
(27) |
6 |
(23) |
0.23 |
54 |
(66) |
37 |
(74) |
3 |
(43) |
0.035 |
|
ARMS2/HTRA1: rs10490924 | ||||||||||||||
| GG |
89 |
(70) |
78 |
(65) |
16 |
(62) |
|
27 |
(33) |
21 |
(42) |
3 |
(43) |
|
| GT |
34 |
(28) |
39 |
(32) |
10 |
(39) |
|
40 |
(49) |
24 |
(48) |
4 |
(57) |
|
| TT |
3 |
(2) |
4 |
(3) |
0 |
0.0 |
0.60 |
15 |
(18) |
5 |
(10) |
0 |
0.0 |
0.18 |
|
CFB: rs641153 (R32Q) | ||||||||||||||
| CC |
101 |
(79) |
91 |
(75) |
19 |
(73) |
|
76 |
(93) |
47 |
(94) |
7 |
100.0 |
|
| CT/TT |
27 |
(21) |
30 |
(25) |
7 |
(27) |
0.57 |
6 |
(7) |
3 |
(6) |
0 |
0.0 |
0.45 |
|
C2: rs9332739 (E318D) | ||||||||||||||
| GG |
116 |
(91) |
106 |
(88) |
24 |
(92) |
|
79 |
(96) |
49 |
(98) |
7 |
100.0 |
|
| CG/CC |
12 |
(9) |
15 |
(12) |
2 |
(8) |
0.71 |
3 |
(4) |
1 |
(2) |
0 |
0.0 |
0.57 |
|
C3: rs2230199 (R102H) | ||||||||||||||
| CC |
82 |
(64) |
74 |
(61) |
14 |
(54) |
|
42 |
(51) |
25 |
(50) |
4 |
(57) |
|
| CG |
44 |
(34) |
40 |
(33) |
11 |
(42) |
|
33 |
(40) |
23 |
(46) |
2 |
(29) |
|
| GG |
2 |
(2) |
7 |
(6) |
1 |
(4) |
0.60 |
7 |
(9) |
2 |
(4) |
1 |
(14) |
0.66 |
|
CFI: rs10033900 | ||||||||||||||
| CC |
36 |
(28) |
40 |
(33) |
11 |
(42) |
|
18 |
(22) |
7 |
(14) |
1 |
(14) |
|
| CT |
59 |
(46) |
64 |
(53) |
11 |
(42) |
|
40 |
(49) |
28 |
(56) |
4 |
(57) |
|
| TT |
33 |
(26) |
17 |
(14) |
4 |
(15) |
0.30 |
24 |
(29) |
15 |
(30) |
2 |
(29) |
0.99 |
|
Neovascular AMD |
Combined Advanced AMD |
|||||||||||||
|
LIPC: rs10468017 genotype |
CC |
CT |
TT |
|
CC |
CT |
TT |
|
||||||
|
N |
% |
N |
% |
N |
% |
p value* |
N |
% |
N |
% |
N |
% |
p value* |
|
|
CFH: rs1061170 (Y402H) | ||||||||||||||
| TT |
37 |
(18) |
24 |
(14) |
4 |
(19) |
|
51 |
(17) |
32 |
(14) |
5 |
(18) |
|
| CT |
98 |
(47) |
77 |
(44) |
9 |
(43) |
|
130 |
(44) |
97 |
(43) |
12 |
(43) |
|
| CC |
76 |
(36) |
73 |
(42) |
8 |
(38) |
0.88 |
112 |
(38) |
95 |
(42) |
11 |
(39) |
0.10 |
|
CFH: rs1410996 | ||||||||||||||
| TT |
10 |
(5) |
5 |
(3) |
1 |
(5) |
|
11 |
(4) |
7 |
(3) |
2 |
(7) |
|
| CT |
62 |
(29) |
44 |
(25) |
6 |
(29) |
|
89 |
(30) |
55 |
(25) |
9 |
(32) |
|
| CC |
139 |
(66) |
125 |
(72) |
14 |
(67) |
0.99 |
193 |
(66) |
162 |
(72) |
17 |
(61) |
0.34 |
|
ARMS2/HTRA1rs10490924 | ||||||||||||||
| GG |
62 |
(29) |
48 |
(28) |
6 |
(29) |
|
89 |
(30) |
69 |
(31) |
9 |
(32) |
|
| GT |
108 |
(51) |
83 |
(48) |
8 |
(38) |
|
148 |
(51) |
107 |
(48) |
12 |
(43) |
|
| TT |
41 |
(19) |
43 |
(25) |
7 |
(33) |
0.16 |
56 |
(19) |
48 |
(21) |
7 |
(25) |
0.49 |
|
CFB: rs641153 (R32Q) | ||||||||||||||
| CC |
191 |
(90) |
162 |
(93) |
20 |
(95) |
|
267 |
(91) |
209 |
(93) |
27 |
(96) |
|
| CT/TT |
20 |
(10) |
12 |
(7) |
1 |
(5) |
0.45 |
26 |
(9) |
15 |
(7) |
1 |
(4) |
0.31 |
|
C2: rs9332739 (E318D) | ||||||||||||||
| GG |
197 |
(93) |
167 |
(96) |
21 |
100 |
276 |
(94) |
216 |
(96) |
28 |
100.0 |
||
| CG/CC |
14 |
(7) |
7 |
(4) |
0 |
0.0 |
0.19 |
17 |
(6) |
8 |
(4) |
0 |
0.0 |
0.16 |
|
C3: rs2230199 (R102H) | ||||||||||||||
| CC |
98 |
(47) |
88 |
(51) |
10 |
(48) |
|
140 |
(48) |
113 |
(50) |
14 |
(50) |
|
| CG |
95 |
(45) |
72 |
(41) |
10 |
(48) |
|
128 |
(44) |
95 |
(42) |
12 |
(43) |
|
| GG |
18 |
(9) |
14 |
(8) |
1 |
(5) |
0.56 |
25 |
(9) |
16 |
(7) |
2 |
(7) |
0.77 |
|
CFI: rs10033900 | ||||||||||||||
| CC |
47 |
(22) |
41 |
(24) |
6 |
(29) |
|
65 |
(22) |
48 |
(21) |
7 |
(25) |
|
| CT |
118 |
(56) |
76 |
(44) |
12 |
(57) |
|
158 |
(54) |
104 |
(46) |
16 |
(57) |
|
| TT | 46 | (22) | 57 | (33) | 3 | (14) | 0.44 | 70 | (24) | 72 | (32) | 5 | (18) | 0.50 |
*P for trend for overall association between number of T alleles for LIPC and number of risk/protective alleles for other genotypes, or presence of at least 1 risk/protective allele for CFB and C2.