Figure 2. Implication of PKA signaling in radiation response.

A. Top molecular pathways affected by radiation identified by MetaCore. B. Western Blotting with PKA motif antibody demonstrates that PKA substrates are differentially phosphorylated following radiation exposure in different subcellular compartments. NHDF cells were exposed to 0 or 50 cGY of ionizing radiation and subcellular fractionation was performed 1 h post-radiation.