Table 4. KEGG pathways affected by radiation.
KEGG pathway | 2 cGy | 50 cGy | ||
Count | Proteins | Count | Proteins | |
Insulin signaling pathway | 8 | MAPK1, PDPK1, IRS2, EIF4EBP1, PRKAR2A, TSC1, PRKAB2, TSC2 | 6 | PDPK1, IRS2, PRKAR2A, EIF4EBP1, TSC1, PRKAB2 |
Pathways in cancer | 7 | EGFR, MAPK1, CCDC6, HDAC1, RALBP1, JUN, ABL1 | 5 | EGFR, HDAC1, PML, LOC652671, ABL1 |
MAPK signaling pathway | 6 | EGFR, MAPK1, JUN, RRAS, STMN1, MAP3K11 | 6 | EGFR, MAP4K4, NF1, RRAS, NFATC4, STMN1 |
mTOR signaling pathway | 6 | EIF4B, MAPK1, PDPK1, EIF4EBP1, TSC1, TSC2 | 4 | EIF4B, PDPK1, EIF4EBP1, TSC1 |
Tight junction | 6 | EPB41L2, RAB3B, TJP1, MAGI1, RRAS, TJAP1 | 4 | EPB41L2, MAGI1, RRAS, TJP2 |
Adherens junction | 6 | EGFR, MAPK1, TJP1, BAIAP2, LMO7, VCL | 3 | EGFR, LMO7, CTNND1 |
Endocytosis | 5 | EGFR, DAB2, RABEP1, SH3KBP1, IQSEC1 | 4 | EGFR, USP8, SH3KBP1, IQSEC1 |
Spliceosome | 1 | SF3B2 | 6 | SFRS4, SFRS9, SNW1, SFRS1, PRPF38B, SF3B2 |
The DAVID web portal was used to calculate statistical enrichment of KEGG pathways.