Table 13.

(9) "Closeness of Fit" Calculations.

	Number of Susceptibility Genes Required (n)
	5	10	11	12	13	14	15
Frequency of Susceptibility (r)	Closeness of Fit (Target ≤4.0)
r = 0.25	24,106	29,422	28,838	28,228	29,694	29,258	28,805
r = 0.33	19,148	4,872	5,600	4,166	4,788	5,416	4,150
r = 0.5	2,139	459	555	451	320	378	189
r = 1	789	90	43.9	39.7	18.9	17.7	9.4
r = 2	394	21.4	12.1	6.9	3.3	2.4	2.5
r = 4	337	9.9	4.4	2.2	1.7	2.1	3.0
r = 8	286	6.8	3.1	1.9	2.3	3.4	4.4
r = 16	262	5.8	2.8	2.4	3.3	4.6	5.8
	Number of Susceptibility Genes Required (n)
	16	17	18	30	40	50	60
Frequency of Susceptibility (r)	Closeness of Fit (Target ≤ 4.0)
r = 0.25	31,198	30,935	31,545	31,749	32,041	32,713	32,776
r = 0.33	3,137	3,593	4,106	1,459	1,280	885	2,042
r = 0.5	228	114	140	21.4	18.3	18.7	38.0
r = 1	5.9	6.2	4.7	8.5	10.6	11.8	11.6
r = 2	3.0	3.6	4.2	10.9	13.5	14.9	12.7
r = 4	4.0	5.1	6.3	13.2	15.5	16.8	14.9
r = 8	5.5	6.8	8.0	14.7	16.7	17.7	16.2
r = 16	6.8	8.1	9.4	15.6	17.3	18.2	18.3

* (Targets are in bold; optimal fit is underlined)

* Calculated as the sum of the squared percent deviations from published epidemiological observations (E) of the high (H) and low (L) estimates derived from the model for non-twin siblings, parents/children, offspring of conjugal MS couples, and second and third degree relatives of MS probands. For each category, this squared percent deviation is defined as: [(H - E)/E + (L - E)/E]²