Table 14.

(10) The Estimated Prevalence and the Number of Loci (n) for susceptible genotypes that include the HLA DRB1*1501 allele.

	Estimated Number of Susceptibility Genes Required (n) for all Loci
	11	12	13	14	15	16	17
Frequency of Susceptibility (r)	Estimated Prevalence of HLA DRB1*1501 in an MS Population (unadjusted; OR ≈ 2.21)
r = 0.25	0.25	0.26	0.24 - 0.26	0.24 - 0.26	0.24 - 0.26	0.25	0.25
r = 0.33	0.32 - 0.37	0.33 - 0.39	0.35	0.32 - 0.36	0.33 - 0.37	0.34 - 0.38	0.34
r = 0.5	0.39 - 0.42	0.38 - 0.44	0.39 - 0.42	0.39 - 0.41	0.39 - 0.42	0.38 - 0.41	0.40 - 0.42
r = 1	0.42 - 0.44	0.41 - 0.43	0.41 - 0.44	0.41 - 0.43	0.41 - 0.43	0.42 - 0.44	0.41 - 0.43
r = 2	0.42 - 0.44	0.41 - 0.44	0.41 - 0.44	0.42 - 0.43	0.41 - 0.43	0.42 - 0.43	0.42 - 0.43
r = 4	0.42 - 0.44	0.42 - 0.44	0.42 - 0.44	0.41 - 0.43	0.42 - 0.43	0.42 - 0.43	0.42 - 0.43
r = 8	0.42 - 0.44	0.42 - 0.44	0.41 - 0.43	0.42 - 0.43	0.42 - 0.43	0.41 - 0.43	0.42 - 0.43
r = 16	0.42 - 0.44	0.42 - 0.44	0.42 - 0.43	0.42 - 0.43	0.42 - 0.43	0.42 - 0.43	0.41 - 0.43
Frequency of Susceptibility (r)	Odd Ratios for Recessive non-HLA DRB1 Loci (after adjustment of HLA to OR = 3.34)
r = 0.25	1.21	1.23	1.05 - 1.23	1.05 - 1.27	1.07 - 1.29	1.07	1.08
r = 0.33	1.57 - 2.03	1.66 - 2.15	1.66 - 2.15	1.51 - 1.82	1.57 - 1.91	1.64 - 2.00	1.70
r = 0.5	1.88 - 2.15	1.79 - 2.30	1.79 - 2.30	1.82 - 2.01	1.91 - 2.12	1.84 - 2.01	1.92 - 2.11
r = 1	1.86 - 2.05	1.82 - 1.98	1.82 - 1.98	1.82 - 1.96	1.85 - 1.98	1.88 - 2.01	1.84 - 1.96
r = 2	1.75 - 1.85	1.73 - 1.85	1.73 - 1.85	1.75 - 1.83	1.74 - 1.84	1.74 - 1.84	1.75 - 1.82
r = 4	1.65 - 1.78	1.66 - 1.75	1.66 - 1.75	1.65 - 1.74	1.66 - 1.74	1.66 - 1.74	1.66 - 1.73
r = 8	1.60 - 1.69	1.60 - 1.69	1.60 - 1.69	1.60 - 1.67	1.60 - 1.67	1.60 - 1.67	1.61 - 1.66
r = 16	1.56 - 1.64	1.56 - 1.64	1.56 - 1.64	1.56 - 1.63	1.56 - 1.62	1.57 - 1.62	1.56 - 1.62

(Bold and underlined as designated for "Closeness of Fit" calculations in Table 8)