Table 7.

(5b) Predicted concordance rates of MS in siblings of MS probands assuming (Pt₀ = Pt₁) and either 100% Dominant genes or 100% Recessive genes.

	Number of Susceptibility Genes Required (n)
	16	17	18	30	40	50	60
Frequency of Susceptibility (r)	Predicted Concordance in Non-twin Siblings (100% of Genes Dominant)
r = 0.25	13.4%	13.4%	13.3 - 13.4%	13.4%	13.4%	13.4%	13.4%
r = 0.33	9.5 - 11.0%	10.7%	10.4 - 11.6%	9.4 - 11.6%	10.4 - 12.0%	10.2 - 12.3%	10.9 - 13.2%
r = 0.5	7.8 - 8.8%	7.2 - 8.2%	7.7 - 8.6%	6.2 - 8.6%	6.7 - 8.1%	6.4 - 8.3%	6.8 - 11.4%
r = 1	6.0 - 6.9%	6.2 - 7.1%	6.0 - 6.8%	5.5 - 6.8%	5.1 - 6.5%	5.1 - 6.1%	4.8 - 9.6%
r = 2	6.0 - 6.8%	6.0 - 6.6%	5.9 - 6.7%	5.2 - 6.4%	4.9 - 6.0%	4.8 - 5.7%	4.6 - 9.2%
r = 4	5.9 - 6.7%	5.8 - 6.6%	5.8 - 6.5%	5.1 - 6.3%	5.0 - 5.9%	4.8 - 5.6%	4.6 - 9.0%
r = 8	5.9 - 6.7%	5.9 - 6.6%	5.8 - 6.5%	5.1 - 6.2%	4.9 - 5.9%	4.8 - 5.6%	4.6 - 9.0%
r = 16	5.9 - 6.6%	5.8 - 6.6%	5.8 - 6.5%	5.2 - 6.2%	5.0 - 5.9%	4.8 - 5.6%	4.6 - 6.8%
Frequency of Susceptibility (r)	Predicted Concordance in Non-twin Siblings (100% of Genes Recessive)
r = 0.25	13.4%	13.4%	13.3 - 13.4%	13.4%	13.4%	13.4%	13.4%
r = 0.33	9.2 - 10.8%	10.5%	10.1 - 11.4%	9.1 - 11.4%	10.5 - 11.8%	9.8 - 12.1%	10.5 - 13.1%
r = 0.5	7.0 - 8.0%	6.3 - 7.4%	6.8 - 7.8%	5.1 - 7.5%	5.2 - 6.7%	4.9 - 6.8%	5.1 - 10.3%
r = 1	4.2 - 5.0%	4.3 - 5.2%	4.1 - 4.9%	3.2 - 4.3%	2.6 - 3.7%	2.3 - 3.1%	1.9 - 6.2%
r = 2	3.3 - 4.1%	3.3 - 3.9%	3.2 - 3.9%	2.1 - 2.9%	1.6 - 2.2%	1.3 - 1.7%	1.0 - 4.0%
r = 4	2.7 - 3.3%	2.6 - 3.2%	2.5 - 3.0%	1.4 - 2.1%	1.0 - 1.5%	0.7 - 1.1%	0.5 - 2.7%
r = 8	2.3 - 2.8%	2.2 - 2.7%	2.1 - 2.5%	1.1 - 1.6%	0.7 - 1.0%	0.5 - 0.7%	0.3 - 1.9%
r = 16	2.0 - 2.5%	1.9 - 2.3%	1.8 - 2.2%	0.8 - 1.3%	0.5 - 0.8%	0.3 - 0.5%	0.2 - 0.6%

(Target = 2.9 - 3.8% is in bold).