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Effects of VPA on the expression of p21WAF1 and cleaved caspase 3 in xenograft model. Immunohistochemical examination showed that p21WAF1-positive cells (nuclear staining) were increased compared with the control group. Cleaved-caspase 3-positive cells were observed as apoptotic cells characterized by cell shrinkage and nuclear fragmentation in the VPA-treated group. Original magnification ×400.
