Table 4.
Enriched functional gene classes in the differential expression profile of metastatic canine mammary tumors
| Functional gene class | Gene number | Enrichment factor |
|---|---|---|
| up-regulated genes | ||
| M-phase | 52 | 17.49 |
| DNA replication | 29 | 6.72 |
| Protein folding | 32 | 6.34 |
| Transcription factors | 48 | 6.21 |
| RNA processing | 50 | 5.99 |
| Apoptosis | 10 | 5.98 |
| Mitochondrion | 59 | 5.96 |
| Cell cycle checkpoint | 14 | 4.09 |
| DNA damage response | 30 | 3.52 |
| Ubiquitin-pathway | 13 | 2.56 |
| DNA-replication initiation | 7 | 2.05 |
| Methyltransferases | 15 | 1.95 |
| RAS-signalling | 5 | 1.71 |
| Prefoldins | 4 | 1.62 |
| Transcription repressors | 13 | 1.32 |
| down-regulated genes | ||
| Transcription factors | 55 | 3.62 |
| mRNA processing | 11 | 3.45 |
| Muscle contraction | 10 | 2.86 |
| Transcription regulation | 41 | 2.36 |
| Cell growth regulation | 10 | 2.03 |
| Methyltransferases | 6 | 1.75 |
| Cell differentiation | 54 | 1.58 |
| Transmembrane tyrosine kinase receptors | 12 | 1.33 |