Table 2.
Allele and Genotype distribution of Nine candidate gene polymorphisms in the study
| Gene | SNP | Allele | DR | DNR | Odds ratio (95% CI) |
P | Genotype | DR (n = 345) |
DNR (n = 359) |
Odds ratio (95% CI)^ |
P |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RAGE | (-374 T/A) | T | 98.10% | 98.52% | 0.77 (0.27-2.15) | 0.62 | TT | 96.21% | 97.05% | 0.76 (0.27-2.13) | 0.62 |
| A | 1.89% | 1.48% | TA | 3.79% | 2.95% | 1.29 (0.46-3.63) | 0.62 | ||||
| (- 429T/C) | T | 86.26% | 83.76% | 1.22 (0.84-1.76) | 0.29 | TT | 74.88% | 71.31% | 1.19 (0.78-1.82) | 0.39 | |
| C | 13.74% | 16.24% | TC | 22.75% | 24.89% | 0.88 (0.57-1.37) | 0.59 | ||||
| CC | 2.37% | 3.80% | 0.61 (0.20-1.86) | 0.38 | |||||||
| rs2070600 | G | 95.1% | 91.9% | 1.7 (1.1-2.6) | 0.016* | GG | 90.4% | 84.1% | 1.78 (1.13- 2.82) | 0.012* | |
| A | 4.9% | 8.1% | GA | 9.3% | 15.6% | 0.55 (0.35-0.88) | 0.011* | ||||
| AA | 0.3% | 0.3% | 1.04 (0.06 -16.7) | 0.97* | |||||||
| PEDF | rs12150053 | T | 77.86% | 76.06% | 1.10 (0.80-1.51) | 0.52 | TT | 60.95% | 58.12% | 1.12 (0.76 -1.64) | 0.54 |
| C | 22.14% | 23.94% | TC | 33.81% | 35.90% | 0.91 (0.61-1.34) | 0.64 | ||||
| CC | 5.24% | 5.98% | 1.04 (0.06-1.95) | 0.73 | |||||||
| rs12948385 | G | 78.33% | 80.17% | 0.89 (0.64-1.23) | 0.49 | GG | 62.38% | 66.67% | 0.82 (0.56-1.22) | 0.34 | |
| A | 21.67% | 19.83% | GA | 31.90% | 27% | 1.26 (0.84-1.90) | 0.25 | ||||
| AA | 5.71% | 6.33% | 0.89 (0.40-1.96) | 0.78 | |||||||
| rs58697961 | G | 50.47% | 51.90% | 0.94 (0.72-1.22) | 0.67 | GG | 27.01% | 26.58% | 1.02 (0.67-1.55) | 0.91 | |
| A | 49.53% | 48.10% | GA | 46.92% | 50.63% | 0.86 (0.59-1.24) | 0.43 | ||||
| AA | 26.07% | 22.78% | 1.19 (0.77-1.84) | 0.41 | |||||||
| rs1136287 | C | 58.17% | 54.03% | 1.18 (0.90-1.54) | 0.21 | CC | 34.13% | 28.40% | 1.30 (0.87-1.95) | 0.19 | |
| T | 41.83% | 45.97% | CT | 48.08% | 51.27% | 0.88 (0.60-1.27) | 0.5 | ||||
| TT | 17.79% | 20.33% | 0.84 (0.52-1.36) | 0.49 | |||||||
| HTRA1 | rs11200638 | G | 61.7% | 70% | 0.68 (0.45-1.01) | 0.055 | GG | 39.34% | 47.68% | 0.64 (0.37-1.1) | 0.11 |
| A | 38.3% | 30.0% | GA | 46.92% | 43.04% | 1.18 (0.69-2.04) | 0.53 | ||||
| AA | 13.74% | 9.28% | 1.86 (0.8-4.3) | 0.14 | |||||||
| EPO | rs1617640 | G | 67.30% | 67.72% | 0.98 (0.74 -1.29) | 0.89 | GG | 43.60% | 43.88% | 0.98 (0.68-1.43) | 0.95 |
| T | 32.70% | 32.28% | GT | 47.39% | 47.68% | 0.98 (0.68-1.43) | 0.95 | ||||
| TT | 9% | 8.44% | 1.07 (0.55-2.07) | 0.83 | |||||||
| ICAM | rs5498 | A | 53.42% | 51.91% | 1.06 (0.81-1.39) | 0.66 | AA | 30% | 27.66% | 1.12 (0.73-1.70) | 0.59 |
| G | 46.58% | 48.08% | AG | 46.84% | 48.51% | 0.93 (0.63-1.37) | 0.73 | ||||
| GG | 23.16% | 23.83% | 0.96 (0.61-1.51) | 0.87 | |||||||
| CFH | rs3753394 | T | 72.03% | 69.49% | 1.13 (0.83-1.53) | 0.42 | TT | 55.36% | 49.15% | 1.28 (0.86-1.89) | 0.21 |
| C | 27.97% | 30.51% | CT | 33.33% | 40.68% | 0.72 (0.48-1.09) | 0.12 | ||||
| CC | 11.30% | 10.17% | 1.12 (0.60-2.10) | 0.71 | |||||||
| rs1061170 | C | 69.86% | 72.25% | 0.89 (0.66 - 1.19) | 0.43 | CC | 48.33% | 50% | 0.93 (0.64-1.35) | 0.72 | |
| T | 30.14% | 27.75% | CT | 43.06% | 44.49% | 0.94 (0.64-1.37) | 0.76 | ||||
| TT | 8.61% | 5.50% | 1.61 (0.77-3.38) | 0.19 | |||||||
| LOC387715 | rs10490924 | T | 62.57% | 68.43% | 0.77 (0.57 - 1.02) | 0.07 | TT | 38.55% | 47.03% | 0.70 (0.47 - 1.04) | 0.08 |
| G | 37.43% | 31.57% | TG | 48.04% | 42.80% | 1.23 (0.83 - 1.82) | 0.28 | ||||
| GG | 13.41% | 10.17% | 1.36 (0.74 - 2.49) | 0.3 |
Chi-square test was used to compare the genotype and allele frequencies between cases and controls.
The SNPs are in Hardy-weinberg equilibrium.
*P-Value < 0.05 is considered to be statistically significant.
^The odds ratio for one genotype was calculated against the other two genotypes combined.