Table 3.

Analysis of RAGE under various models in the exploratory and confirmatory sets

Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio (95% CI)	P
RAGE	rs2070600	G	95.1%	91.9%	1.7 (1.1 -2.6)	0.0162	SNP		0.042
		A	4.9%	8.1%	0.59 (0.38-0.91)		Dominant	OR = 0.56 (0.35 - 0.89)1	0.0122
							Additive	R = -0.091	0.0163
1(AA,AG)/AA 2χ2, P-Value < 0.05 is considered to be statistically significant. 3Trend, P-Value < 0.05 is considered to be statistically significant.
Genotype and allele frequencies of RAGE in the confirmatory set:
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio/R (95% CI)	P
RAGE	rs2070600	G	96.5%	92.2%	1.78 (1.22 -2.60)	0.068	SNP		0.0352
		A	3.5%	7.8%	0.54 (0.38-0.76)		Dominant	OR = 0.34 (0.13 - 0.94)1	0.0322
							Additive A	R = -0.129	0.073

*includes the exploratory, confirmatory sets and that of Kumaramanickavel et al.

¹(AA,AG)/AA

²χ², P-Value < 0.05 is considered to be statistically significant.

³Trend, P-Value < 0.05 is considered to be statistically significant (not corrected for multiple testing).