Table 4.

Analysis of combined sets under various models

Genotype and allele frequencies of RAGE gene polymorphism rs2070600 in the exploratory and confirmatory sets combined:
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio (95% CI)	P
RAGE	rs2070600	G	95.4%	92%	1.8 (1.2 -2.7)	0.0032	SNP		0.0032
		A	4.6%	8%	0.55 (0.37-0.82)		Dominant	0.51 (0.34 - 0.77)1	0.00132
							Additive	R = -0.0997	0.0033
Genotype and allele frequencies of RAGE in all sets combined*:
Gene	SNP	Allele	DR	DNR	Odds ratio (95% CI)	P	Model	Odds ratio/R (95% CI)	P
RAGE	rs2070600	G	95.2%	91.4%	1.78 (1.22 -2.60)	0.0003*	SNP		0.00032
		A	4.8%	8.6%	0.54 (0.38-0.76)		Dominant	0.49 (0.34 - 0.70)1	0.000112
							Additive A	R = -0.10548	0.000473

*includes the exploratory, confirmatory sets and that of Kumaramanickavel et al.

¹(AA,AG)/AA

²χ², P-Value < 0.05 is considered to be statistically significant.

³Trend, P-Value < 0.05 is considered to be statistically significant (not corrected for multiple testing).