Table 4.

Characteristics of colorectal cancers as a function of receipt of androgen deprivation^*

Androgen deprivation	No. colorectal cancer patients	Tumor stage†		Tumor grade‡		Site of tumor§
		% Localized	P║	% Poorly differentiated or undifferentiated	P║	% Distal	P║
None	1048	48.0	.073	21.4	.013	53.1	.489
GnRH agonist	849	51.8		18.6		55.6
Orchiectomy	138	41.5		30.6		52.2

^*GnRH = gonadotropin-releasing hormone; SEER = Surveillance, Epidemiology, and End Results.

^† Based on SEER historical staging system, categorized as in situ or localized, regional, or distant spread; for the 1701 patients diagnosed from SEER files and having stage information available.

^‡Based on SEER grading system, categorized as well differentiated, moderately differentiated, poorly differentiated or undifferentiated; for the 1676 patients diagnosed from SEER files and having grade information available.

^§Site of tumor categorized as proximal (cecum through splenic flexure) vs distal (descending colon through rectum) based on SEER files.

^║All P values are two-sided and are based on χ² tests for differences in the proportion of colorectal tumors with the characteristic of interest across the androgen deprivation exposure groups.