Table 3. Agonist and antagonist characteristics at the turkey β3C-adrenoceptor.

tβ3C	Log EC50	% isop max	n	Log KD propranolol	n	Log KD CGP20712A		Log KD ICI118551	n	Log KD CGP12177	n
fenoterol	−9.08±0.08	105.9±3.0	16	−9.01±0.04	4	−5.61±0.11	6	−9.34±0.07	4	−9.94±0.08	9
formoterol	−10.35±0.05	103.6±3.0	19	−8.78±0.05	14	−5.44±0.10	6	−9.29±0.06	5	−9.71±0.07	10
BRL37344	−7.67±0.04	88.5±4.2	16	−9.01±0.12	5	−5.51±0.12	7	−9.31±0.07	4	−9.73±0.11	7
cimaterol	−9.36±0.08	103.1±2.2	17	−8.93±0.08	13	−5.46±0.06	5	−9.40±0.06	4	−9.58±0.07	11
clenbuterol	−9.28±0.06	97.8±4.4	17	−8.95±0.06	13	−5.75±0.06	4	−9.47±0.05	4	−9.78±0.07	10
salmeterol	−10.43±0.06	96.0±5.7	18	−8.90±0.09	5	−5.20±0.12	8	−9.21±0.08	5	−9.76±0.11	7
salbutamol	−8.45±0.06	101.8±3.1	16	−8.90±0.07	4	−5.49±0.10	7	−9.31±0.09	4	−9.71±0.11	6
adrenaline	−7.20±0.09	105.9±2.7	17	−8.24±0.07	11	−5.34±0.09	6	−8.79±0.08	7	−9.37±0.08	10
noradrenaline	−6.38±0.07	101.8±3.0	20	−8.45±0.10	13	−5.28±0.11	5	−8.86±0.11	6	−9.18±0.10	9
isoprenaline	−7.57±0.09	100	19	−8.13±0.09	13	−5.43±0.10	4	−8.60±0.11	8	−9.11±0.11	11
dobutamine	−6.37±0.06	100.8±3.7	15	−8.45±0.09	4	−5.13±0.09	5	−8.94±0.09	4	−9.00±0.09	6
CGP12177	−9.66±0.06	39.9±3.2	19	−8.95±0.08	11	−5.57±0.15	8	−9.50±0.08	10

Log EC₅₀ values and % isoprenaline maximal responses obtained from CRE-SPAP production in CHO tβ3C cells. Log K_D values for propranolol, CGP20712, ICI118551 and CGP12177 as antagonists of the agonist responses are also given. Values are mean ± s.e.m. of n separate determinations.