Table 3.
Degrees and duplicabilities of the genes in the yeast PIN belonging to each functional category
| GO biological process category | Mean degreea | Mean duplicabilitya | # of proteins |
|---|---|---|---|
| Lipid metabolic process | 2.2 | 0.79 (---) | 127 |
| Cellular respiration | 2.2 | 0.34 | 57 |
| Vitamin metabolic process | 2.6 | 1.33 (+) | 51 |
| Cofactor metabolic process | 2.6 | 0.72 | 86 |
| Translation | 2.6 | 0.70 | 167 |
| Aromatic compound metabolic process | 2.9 | 0.50 | 42 |
| Heterocycle metabolic process | 2.9 | 0.40 | 48 |
| Carbohydrate metabolic process | 3.1 | 1.80 (+++) | 97 |
| Amino acid and derivative metabolic process | 3.6 | 0.81 | 124 |
| Generation of precursor metabolites and energy | 3.9 | 0.86 | 95 |
| Sporulation | 4.0 | 0.66 | 84 |
| Cell wall organization and biogenesis | 4.1 | 1.42 (+++) | 129 |
| Response to chemical stimulus | 4.1 (+) | 1.05 (+++) | 271 |
| Protein modification process | 4.1 (++) | 0.72 | 368 |
| Cellular homeostasis | 4.2 | 1.12 | 63 |
| DNA metabolic process | 4.5 | 0.42 (---) | 244 |
| Protein catabolic process | 4.7 (+) | 0.31 (---) | 119 |
| Meiosis | 4.7 (++) | 0.27 (-) | 104 |
| Transport | 4.8 (+++) | 1.93 (+) | 649 |
| Response to stress | 4.8 (+++) | 0.72 | 348 |
| Organelle organization and biogenesis | 4.9 (+++) | 0.46 (---) | 947 |
| Vesicle-mediated transport | 5.3 (+++) | 0.56 | 261 |
| Cell cycle | 5.3 (+++) | 0.49 | 292 |
| Pseudohyphal growth | 5.4 | 0.83 | 50 |
| Signal transduction | 5.6 (+++) | 1.08 (+) | 168 |
| Membrane organization and biogenesis | 5.7 (+++) | 0.64 | 149 |
| RNA metabolic process | 6.0 (+++) | 0.18 (---) | 496 |
| Cytokinesis | 6.1 (+++) | 0.62 | 91 |
| Transcription | 6.3 (+++) | 0.22 (---) | 178 |
| Conjugation | 6.4 (+++) | 0.71 | 89 |
| Anatomical structure morphogenesis | 6.8 (+++) | 0.63 | 115 |
| Cell budding | 7.5 (+++) | 0.78 | 70 |
| All proteins in the yeast PIN | 3.7 | 0.92 | 3,891 |
NOTE. Functional categories containing five or more proteins are shown. Genes in the MIPS database were used.
a. The mean among the proteins contained in each functional category. +++, ++, and + (or ---, --, and -) indicates that a given value is significantly higher (or lower) with P < 0.001, P < 0.01, and P < 0.05, respectively, by the Wilcoxon rank-sum two-sample test with the Bonferroni correction.