Table 3. Genotype distribution of chromosome 9p21 SNPs according to carotid plaque status (n = 810).
SNP/genotype | Carotid plaque, N (%) | OR (95%CI) | p* value | |
No plaque | Any plaque | |||
rs1333040 | ||||
CC | 48 (9.21) | 22 (8.03) | 1.00 | |
CT | 225 (43.19) | 103 (37.59) | 1.06 (0.58–1.93) | 0.849 |
TT | 248 (47.60) | 149 (54.38) | 1.39 (0.78–2.55) | 0.274 |
rs2383207 | ||||
AA | 72 (13.87) | 29 (10.66) | 1.00 | |
AG | 222 (42.77) | 118 (43.38) | 1.40 (0.84–2.39) | 0.179 |
GG | 225 (43.35) | 125 (45.96) | 1.56 (0.93–2.67) | 0.071 |
rs1333049 | ||||
GG | 166 (31.62) | 65 (23.72) | 1.00 | |
GC | 238 (45.33) | 136 (49.64) | 1.57 (1.06–2.33) | 0.024 |
CC | 121 (23.05) | 73 (26.64) | 1.75 (1.12–2.75) | 0.015 |
*Permutation p value after being adjusted for age, sex, hypertension, diabetes, hypercholesterolemia, body mass index and current smoking