Figure 3. Characterization of TCF4 binding peaks.

A) Number of peaks with at least one TCF4 binding motif in relation to the protein-DNA interaction strength. Peaks containing more reads (lower bin numbers) more often harbor a TCF4 binding motif compared to weaker ones. B) Conservation profile of experimentally identified TCF4 binding regions as well as all genomic regions containing the TCF4 consensus binding motif as compared to random regions. Experimentally identified binding regions were found to be more conserved than computationally predicted sites.