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. 2010 Nov 30;5(11):e15128. doi: 10.1371/journal.pone.0015128

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Medendorp et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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HEK293/T-REx/PRCCTFE3 cells were transiently transfected with a H2B-RFP construct (see Materials and methods) and grown with or without tetracyclin (+/− PRCCTFE3), respectively. Subsequently, mitotic cells were scored for misaligned chromosomes. Percentages of cells with misalignments, such as centrophilic chromosomes, anaphase bridges and lagging chromosomes, are shown in the histogram. Black bars represent un-induced cells (- PRCCTFE3), and white bars represent induced cells (+PRCCTFE3). In the right panel, PRCCTFE3 protein expression in the induced (+ tetracyclin) cells is shown.