Table 5.
Prediction of 5-year risk of geographic atrophy by risk score without consideration of night vision score (N=942 patients)
| GA risk score | N | Endpoint GA | Central GA | GA anywhere | |||
|---|---|---|---|---|---|---|---|
| In either eye (n=64) | In untreated eye (n=45) | In either eye (n=90) | In untreated eye (n=68) | In either eye (n=324) | In untreated eye (n=214) | ||
| <5 | 193 | 3 (1.55) | 2 (1.04) | 2 (1.04) | 1 (0.52) | 24 (12.4) | 12 (6.22) |
| 5–6 | 100 | 3 (3.00) | 1 (1.00) | 4 (4.00) | 3 (3.00) | 23 (23.0) | 16 (16.0) |
| 7 | 114 | 7 (6.14) | 5 (4.39) | 9 (7.89) | 7 (6.14) | 32 (28.1) | 17 (14.9) |
| 8 | 270 | 26 (9.63) | 16 (5.93) | 27 (10.0) | 19 (7.04) | 116 (43.0) | 78 (28.9) |
| 9 | 224 | 19 (8.48) | 16 (7.14) | 39 (17.4) | 32 (14.3) | 107 (47.8) | 77 (34.4) |
| 10 | 41 | 6 (14.6) | 5 (12.2) | 9 (22.0) | 6 (14.6) | 22 (53.7) | 14 (34.2) |
| AUC (95% CI*) | 0.67 (0.62–0.72) | 0.69 (0.64–0.75) | 0.71 (0.66–0.76) | 0.72 (0.67–0.77) | 0.68 (0.64–0.71) | 0.68 (0.64–0.72) | |
AUC = area under the receiver operating characteristic curve; GA = geographic atrophy; CI = Confidence interval.
*
Based on the bootstrap of 2000 sample.