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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Hepatol. 2010 Sep 6;54(1):164–172. doi: 10.1016/j.jhep.2010.08.007

Figure 6. Diagram illustrating a role for p53 in ALD.

Figure 6

Activation of p53 is linked to hepatic steatosis and oxidative stress. Enhanced p53 expression promotes apoptosis, suppresses insulin signaling and cell survival, as well as shifts energy metabolism towards ROS-prone oxidative phosphorylation, decreases glycolysis and favors gluconeogenesis. In this context, increased HGP enhances systemic insulin resistance and further promotes steatosis by activating SREBP1c. Grey boxes represent the results of signaling abnormalities during chronic ethanol consumption.