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Summary cartoon. ABA binding induces closure of the gate loop (pink) onto the latch (green). The new gate-latch interface binds in turn to the active site and the protruding domain of PP2Cs, which inhibits PP2C activity by blocking substrate access to the active site. Arrows indicate key interactions, yellow balls the catalytic Mg2+ ions, and the small red ball the water molecule that mediates the interaction between HAB1 W385 and the ABA ketone group.
