Representative traces showing 20μM ryanodine having no effect on A, bitter (10mM denatonium benzoate) C, umami (10mM MPG) and E, sweet (2mM saccharin) evoked calcium responses in dual-responsive taste cells. Pooled results showing lack of significant inhibition by ryanodine in dual-responsive cells for B, denatonium (n=29, P=0.11), D, MPG (n=19, P=0.72) and F, saccharin (n=9, P=0.69)