Table 2.
Standardized incidence ratios (SIRs) by proband characteristics (age, tumor histology), relative age at diagnosis, and relationship for all cancers in first-degree relatives
| Number | P-Y | Obs | Exp | SIR | 95% CI | |
|---|---|---|---|---|---|---|
| Proband Age | ||||||
| Proband less than 35 years | 1664 | 59031 | 108 | 74.80 | 1.44 | 1.18-1.74 |
| Proband between 35 and 50 years | 3327 | 139382 | 356 | 269.31 | 1.32 | 1.19-1.47 |
| Proband greater than 50 years | 3755 | 193371 | 537 | 481.37 | 1.12 | 1.02-1.21 |
| Proband’s histology | ||||||
| High Grade | 4377 | 209204 | 564 | 480.39 | 1.17 | 1.08-1.28 |
| Anaplastic | 2646 | 112745 | 277 | 216.83 | 1.28 | 1.13-1.44 |
| Low grade | 1555 | 64060 | 148 | 118.99 | 1.24 | 1.05-1.46 |
| Relative’s Age | ||||||
| Relative less than 45 years | 4514 | 123334 | 262 | 51.55 | 5.08 | 4.49-5.74 |
| Relative >= 45 years | 4232 | 268450 | 739 | 773.93 | 0.89 | 0.89-1.03 |
| Relationship | ||||||
| Fathers | 1418 | 90451 | 352 | 297.98 | 1.18 | 1.06-1.31 |
| Mothers | 1436 | 93487 | 341 | 295.22 | 1.16 | 1.04-1.28 |
| Siblings | 3345 | 148941 | 277 | 210.17 | 1.32 | 1.17-1.48 |
| Offspring | 2547 | 58905 | 31 | 22.12 | 1.40 | 0.95-1.99 |
| TOTAL | 8746 | 391784 | 1001 | 825.48 | 1.21 | 1.14-1.29 |