Table 1.

Assigning biological conditions to FMRMs

FMRM#	ci	x	Mouse model class	Tumor subtype	P-value
3	10	3	C3TAg	Basal	0.0081
4	8	3	MMTV-Wnt	Luminal	0.004
5	10	3	Hras	Luminal	0.0081
6	14	3	p53	Basal	0.0222
11	10	3	C3TAg	Basal	0.0081
13	14	3	p53	Basal	0.0222
19	10	3	BRCA_p53	Basal	0.0081

According to Equation (4), biological conditions are assigned to FMRMs based on a hypergeometric distribution. The significant results are given in this table. The size of population is 92, the number of each draw is 5% of the population, i.e. 5. c_i is the number of samples belonging to each condition, which include both over- and underexpressed status. x denotes the observed number of samples with the assigned biological condition in each draw. FMRM# is the module number corresponding to the number in Figure 2.