Table 3.
Validation of identified miRNAs in the FMRMs
| FMRM# | Supported miRNAs | Coverage | P-value |
|---|---|---|---|
| 3 | let-7a, let-7b, let-7c, | 8/33(22.24%) | 0.02641 |
| let-7d, let-7e, let-7f, | |||
| miR-221,miR-29a | |||
| 4 | let-7a, let-7b, let-7c,let-7d, | 10/18(55.56%) | 6.68E-06 |
| let-7e, let-7f, let-7g, let-7i, | |||
| miR-21,miR-221 | |||
| 5 | let-7b, let-7c, let-7d, | 9/17(52.94%) | 3.56E-05 |
| let-7i, miR-200b, miR-200c, | |||
| miR-29a, miR-29b, miR-30c | |||
| 6 | let-7a, let-7b, let-7c, | 8/16(50.00%) | 1.76E-04 |
| let-7d, let-7i, miR-103, | |||
| miR-21, miR-221 | |||
| 15 | let-7a, let-7c,let-7f, | 9/17(52.94%) | 3.56E-05 |
| let-7g, miR-141, miR-19b, | |||
| miR-21, miR-200a,miR-200b | |||
| 19 | let-7a, let-7b, let-7c, | 11/18(61.11%) | 5.45E-07 |
| let-7d, let-7e, let-7f, | |||
| miR-143, miR-145, | |||
| miR-21, miR-29a, miR-29b |
The comparison shows that significant numbers of miRNAs identified in the FMRMs are relevant to cancers. From the literature, 42 miRNAs have been validated as either oncogenes or tumor suppressors (details in Supplementary Material). Among the 334 miRNAs under investigation, a significant number of miRNAs in identified modules are supported by the current knowledge. The coverage is the percentage of the number of miRNAs in each module supported by literature. P-value is calculated by a hypergeometric probability density function at each of the numbers of miRNAs supported by the literature, using the corresponding size of the total miRNAs under investigation (334), numbers of miRNAs in each module and numbers of miRNAs identified from the literature (42). The modules with significant supports are given in this table.