Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Dec;136(6):659–671. doi: 10.1085/jgp.201010518

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 Kopeikin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Effects of CFTRinh-172 on the open time of WT-CFTR. (A and B) Single-channel traces showing a reversible decrease of the open time in the presence of CFTRinh-172 for (A) ATP- and (B) P-ATP–gated channels. Dashed lines represent the current level of the closed state. (C) The mean open time (τ_o) decrease as a result of 5 µM CFTRinh-172 for channels opened with ATP (n = 10) or P-ATP (n = 7). The mean closed time (τ_c) was prolonged by CFTRinh-172 (τ_c = 637.3 ± 59.2 ms in the absence of CFTRinh-172 and 2,580.5 ± 623.4 ms in the presence of 5 µM CFTRinh-172). For channels opened with P-ATP, τ_c = 670.8 ± 55.8 ms and 2,058.3 ± 254.2 ms in the absence and presence of CFTRinh-172, respectively.