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. 2010 Dec;136(6):659–671. doi: 10.1085/jgp.201010518

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© 2010 Kopeikin et al.

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Figure 7. — Reopening of inhibited E1371S-CFTR channels upon removing CFTRinh-172. A continuous recording of E1371S-CFTR, a hydrolysis-deficient mutant with a prolonged open time, shows reopening of the inhibited channels in the absence of ATP upon removal of CFTRinh-172. Note that the channels can reopen into the locked-open state. Because some of the reopened channels are expected to close during such a long recording in the absence of ATP, the number of reopened channels is underestimated if one simply counts the opening events. Similar observations were made in more than 30 patches.