Table 1.
Study population characteristics and genotypes by tumor histology
| By Histology |
|||||
|---|---|---|---|---|---|
| All cases (%) | High Grade (%) | Medium/Low Grade | (%) p-value | ||
| (n=694) | (n=343) | (n=351) | |||
| Sex | |||||
| Male | 419 (60) | 210 (61) | 209 (60) | ||
| Female | 275 (40) | 133 (39) | 142 (40) | 0.65 | |
| Chemotherapy | |||||
| Yes | 473 (70) | 233 (72) | 240 (69) | ||
| No | 201 (30) | 92 (28) | 109 (31) | 0.41 | |
| Radiation Therapy | |||||
| Yes | 573 (83) | 306 (89) | 267 (76) | ||
| No | 121 (17) | 37 (11) | 84 (24) | <.0001 | |
| Surgery Extent | |||||
| Gross Total | 305 (44) | 158 (52) | 147 (48) | ||
| Subtotal | 388 (56) | 185 (48) | 203 (52) | 0.28 | |
| Age at diagnosis | |||||
| median (range) | 45.50 (18.00–72.80) | 52.29 (20.10–72.80) | 38.32 (18.00–65.00) | ||
| mean (sd) | 44.62 (11.78) | 50.38 (9.85) | 38.99 (10.76) | <.0001 | |
| IL4 rs243250 | |||||
| CT/TT | 194 (30) | 94 (29) | 100 (31) | ||
| CC | 449 (70) | 227 (71) | 222 (69) | 0.62 | |
| IL13 rs1800925 | |||||
| CT/TT | 240 (37) | 116 (36) | 124 (39) | ||
| CC | 403 (63) | 205 (64) | 198 (61) | 0.53 | |
| IL4R rs1805011 | |||||
| AC/CC | 133 (21) | 68 (21) | 65 (20) | ||
| AA | 511 (79) | 253 (79) | 258 (80) | 0.73 | |
| IL4R rs1805012 | |||||
| CT/CC | 126 (20) | 65 (20) | 61 (19) | ||
| TT | 517 (80) | 257 (80) | 260 (81) | 0.71 | |
| IL4R rs1805015 | |||||
| CT/CC | 188 (29) | 99 (31) | 89 (28) | ||
| TT | 454 (71) | 220 (69) | 234 (72) | 0.33 | |
| IL4R rs1801275 | |||||
| AG/GG | 232 (36) | 121 (38) | 111 (34) | ||
| AA | 412 (64) | 200 (62) | 212 (66) | 0.38 | |
| IL4R rs1805016 | |||||
| GT/GG | 71 (11) | 37 (12) | 34 (11) | ||
| TT | 573 (89) | 284 (88) | 289 (89) | 0.69 | |