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Distribution of Nopp140 in a HeLa cell during interphase observed by confocal microscopy. (a): phase contrast. (b): optical section. (c): projection of the z-series. (d): surfacic visualization of the volume. Results show a strong labelling localised in the cell nucleoli and in the nuclear Cajal bodies. As revealed by three-dimensional reconstructions, the nucleolar labelling is organized as spherical spots grouped in clusters (c and d). Bar is 5 μm
