Figure 1.

Mammalian Rap1 resembles yeast and trypanosome Rap1. Top: The mammalian shelterin complex and its role in repressing HDR at chromosome ends. Bottom: Schematic representation of the conserved protein motifs of Rap1 and its TRF2-like partners in the indicated organisms. MYB indicates regions with a MYB sequence. Myb-fold indicates a motif that lacks sequence similarity to the MYB sequence but has a similar fold. The cyan boxes in Rap1 of S. pombe and T. brucei indicate that while these proteins have sequence similarity to the Myb-fold of S. cerevisiae, their structure has not been determined. It is not known whether Rap1 of S. pombe and T. brucei have an RCT domain but the C-terminus of T. brucei Rap1 is not required for its interaction with its TRF interacting partner.