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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Mol Cell. 2009 Dec 25;36(6):920–921. doi: 10.1016/j.molcel.2009.12.013

Figure 1. Models for HuD-mediated translation enhancement.

Figure 1

(A) General translation enhancement. This model proposes that HuD functions as an autonomous translation activator through its interactions with eIF4A and the poly(A) tail.

(B) Transcript-specific translation enhancement. This model proposes that HuD first associates with mRNA targets through binding to AU-rich or U-rich sequences (e.g., ARE) in the 3' UTRs to exert its translation enhancing effect.