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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Hypertension. 2010 Sep 13;56(5):871–878. doi: 10.1161/HYPERTENSIONAHA.110.154559

Figure 1.

Figure 1

Effect of AT1R blockade and 20-HETE inhibition on blood pressure in VECAD-CYP4A2-transduced rats. Rats were injected with Lenti-VECAD-CYP4A2 (A) or the Lenti-VECAD-GFP (B) and treated with and without HET0016 (HET; 10mg/kg/day). At day 27, Losartan (100 mg/kg) was added to the drinking water of Lenti-VECAD-CYP4A2-injected rats (A) for 3 days (n=4, *p<0.05 vs day 0, ‡p<0.05 vs day 30). C) Creatinine clearance (Ccr) in lenti-VECAD-GFP transduced and lenti-VECAD-CYP4A2 transduced rats with and without HET0016 was measured at the end of the experiment (n=4; *p<0.01 vs control; ‡p<0.01 vs CYP4A2).