Fig. 1.

H&E sections of the ovary from rats exposed to vehicle (CONT, a), DMBA (10 mg/wk, b), tamoxifen (TAM, c), or DMBA+TAM (d) for 2 weeks. Arrowheads = representative primordial follicles. Arrows = representative primary follicles. DMBA decreased follicular reserves in the ovary (b) compared with vehicle-treated controls (a) and the addition of tamoxifen inhibited this depletion (d). Tamoxifen alone elevated the number of follicles in the ovary compared with vehicle-treated controls (c). Numbers of follicle loss relative to vehicle-treated controls are shown for total (follicles at all developmental stages) follicle populations and are calculated by subtracting the control group mean value. The loss of follicles was expressed by a positive number whereas gain of follicles was expressed as a negative number. Different letters indicate significant differences among treatment groups