Fig. 2.

H&E sections of the ovary from rats exposed to vehicle (CONT, a), cyclophosphamide (Cy, 50 mg/kg, b), tamoxifen (TAM, c), or Cy+TAM (d) for 4 weeks. Arrowheads = representative primordial follicles. Arrows = representative primary follicles. Cy decreased total numbers of follicles (b) in the ovary compared with vehicle-treated controls (a) and the addition of tamoxifen inhibited this depletion (d). TAM did not affect the number of follicles in the ovary compared with vehicle-treated controls (c). Numbers of follicle loss relative to vehicle-treated controls are shown for total and primordial follicle populations. Cy treatment at 35 and 50 mg/kg/wk induced follicle loss compared with controls and the addition of TAM to both doses of Cy inhibited this depletion. Different letters indicate significant differences among treatment groups