Table 2.
The frequency of under- and over-methylated cases as determined based on intermediate methylation levels common in the H. pylori-negative gastric mucosa (n = 100)
| Gene name | Intermediate methylation density | No. of under- methylated cases | No. of intermediate methylation cases | No. of over- methylated cases |
|---|---|---|---|---|
| CpG-island containing genes | ||||
| CDH1 | 0 - 20% | 0 | 79 | 21 |
| ARRDC4 | 0 - 20% | 0 | 80 | 20 |
| PPARG | 0 - 20% | 0 | 60 | 40 |
| CDKN2A | 0 - 20% | 0 | 54 | 46 |
| TRAPPC2L | 40 - 60% | 13 | 81 | 6 |
| DUSP6 | 20 - 40% | 26 | 62 | 12 |
| MLH1 | 20 - 40% | 20 | 61 | 19 |
| RUNX3 | 30 - 50% | 5 | 53 | 42 |
| CpG-island lacking genes | ||||
| PGA5 | 40 - 60% | 10 | 78 | 12 |
| PGC | 40 - 60% | 29 | 67 | 4 |
| TFF1 | 20 - 40% | 11 | 52 | 37 |
| TFF2 | 30 - 50% | 36 | 60 | 4 |
| MSLN | 60 - 80% | 0 | 88 | 12 |
| KRT6A | 60 - 80% | 17 | 65 | 18 |