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Structure of the reductase (R) domain within CpFAS1 and its catalyzed reaction. A) Illustration of the position and conserved NAD(P)H-binding and reductive motifs of the R domain within the CpFAS1 megasynthase. B) Proposed reactions catalyzed by CpFAS1 including that by the R domain. Newly elongated carbon chains are shown in red, while the hydrogen groups donated from NAD(P)H are shown in blue.
