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Schematic of the TCA cycle, demonstrating incorporation of 13C label from plasma [2-13C]acetate into the muscle [4-13C]glutamate pool. *The carbon position labeled with 13C. Pyr, pyruvate; FFA, free fatty acids; AcCoA, acetyl-CoA; αKG, α-ketoglutarate. A single turn of the TCA cycle is shown; a second turn of the cycle forms [2-13C]glutamate and [3-13C]glutamate.
