Figure 2 Absence of cortical demyelination and preservation of aquaporin-4 (AQP4) in hippocampus and cerebellar cortex of patients with neuromyelitis optica (NMO)

Cortical demyelination is absent and AQP4 is preserved in a normal distribution in the hippocampus (A-I) and cerebellar cortex of patients with NMO (J-O). Dentate gyrus (B-C), CA4 (D-E), CA3-2 (F-G), and CA1 (H-I) show preservation of myelin (B, D, F, H) and AQP4 (C, E, G, I). The myelin is preserved in the molecular, infraganglionic, and supraganglionic layers of the cerebellum¹³ (J, L, N) and AQP4 immunoreactivity is most intense in Bergmann glia and astrocytes of the granule cell layer (K, M, O). (A, B, D, F, H, J, L, N) Proteolipid protein. (C, E, G, I, K, M, O) AQP4. (A) Scale bar = 1 mm. (B-I, L, M) Scale bar = 250 μm. (J, K) Scale bar = 500 μm. (N, O) Scale bar = 100 μm. DG = dentate gyrus; CA4 = field 4 of cornu Ammonis; CA3-2 = fields 3 and 2 of cornu Ammonis; CA1 = field 1 of cornu Ammonis.