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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Lancet. 2010 Jun 26;375(9733):2267–2277. doi: 10.1016/S0140-6736(10)60408-4

Figure 1. Glucose-fatty-acid cycle proposed by Randle and colleagues.

Figure 1

CoA=coenzyme A. PDH=pyruvate dehydrogenase. PFK=phosphofructokinase. G6P=glucose-6-phosphate. HK=hexokinase. Red circle with minus sign represents inhibition. Black line with arrowhead represents increase or accumulation of substrate. Blue dotted line with arrowhead indicates a pathway that is inhibited.