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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Int J High Throughput Screen. 2010 Jul;2010(1):127–140. doi: 10.2147/IJHTS.S10547

Figure 6.

Figure 6

Pilot screening results from the Prestwick FDA-approved drug library. (A) Pilot screen scatter for the 1120 compound Prestwick library. Response in this assay is calculated as a percent-effect as compared with the positive control. A cursory hit threshold is drawn at <32% effect, representing the μ + 3σ (B) Dose response confirmation for the active compound niclosamide (inset) showing a 2.4 μM EC50 and correlating western blot (left lane = DMSO, right lane = positive control) normalized to tubulin. Increased GFP expression correlates with increased peroxisomal specific antigen PMP-70 (↑33%).

Abbrevation: U, arbitrary fluorescent units.