Table 6.
Impact of the computerized provider order entry (CPOE) system on medication errors, description of multivariate model
| Coefficient (OR) adjusted1 2 | 95% CI for coefficient (95% CI for OR)‡ | |
| Predictor of interest | ||
| e-prescribing (eRx) | −1.19 (0.30) | −1.48 to −0.91*** (0.23 to 0.40) |
| Main effects | ||
| Age≥65 years | 0.35 (1.42) | 0.08 to 0.64** (1.08 to 1.90) |
| Female | −0.14 (0.87) | −0.30 to 0.03 (0.74 to 1.03) |
| Therapeutic drug class | ||
| Antibiotics | −0.61 (0.54) | −0.88 to −0.34*** (0.41 to 0.71) |
| Antidepressants | −0.46 (0.63) | −0.97 to 0.06 (0.38 to 1.06) |
| CNS agents | 0.09 (1.09) | −0.43 to 0.60 (0.65 to 1.82) |
| Hormonal agents | −0.46 (0.63) | −0.89 to −0.03* (0.41 to 0.97) |
| Schedule II–V agents | 0.79 (2.20) | 0.47 to 1.10*** (1.60 to 3.00) |
| Clinic site A | −0.37 (0.69) | −0.67 to −0.06* (0.51 to 0.94) |
| Clinic site B | −0.06 (0.94) | −0.50 to 0.33 (0.61 to 1.39) |
| Clinic site C | 0.13 (1.14) | −0.26 to 0.52 (0.77 to 1.68) |
| Interaction terms | ||
| CPOE and CNS agents | 0.55 (1.73) | −0.15 to 1.25 (0.86 to 3.49) |
| CPOE and hormonal agents | 0.69 (1.99) | 0.09 to 1.29* (1.09 to 3.63) |
| CPOE and Schedule II–V agents | 0.52 (1.68) | 0.08 to 0.96* (1.08 to 2.61) |
| CPOE and clinic site C | −0.57 (0.57) | −1.00 to −0.14** (0.37 to 0.87) |
*
p<0.05
**
p<0.01
***
p<0.001.
‡
Generalized estimating equations with independent correlation structure; clustering at the prescriber level; prescription weighting schema applied; Adjusted model contains the following variables: Main effects: age (< ≥65), gender, antibiotics, antidepressants, hormones, Schedule II–V agents (referent is all other therapeutic classes), clinic site C (referent is clinic site A); Interaction terms: eRx×hormones, eRx×Schedule II–V agents, eRx×site C.
CNS, central nervous system.