Table 5.

Events, including probabilities for endpoints occurring, nursing cost for following a patient one year for immunosuppressive management, and quality of life-years, in a cost-effectiveness analysis

Event in cost-effectiveness analysis	No endpoint	Endpoints rejection episode	Tacrolimus toxicity
Incidence
Paper system*		0.22 (0.17 to 0.27)†	0.31 (0.26 to 0.37)†
Automated clinical review system*		0.06 (0.03 to 0.12)†	0.18 (0.12 to 0.26)†
Cost
Nursing cost to follow a patient for a year‡
Paper system	$1556 (range 777 to 5055)
Automated clinical review system	$189 (range 92 to 972)
Nursing cost per event§		$142.95 (74.33 to 337.36)	$68.61 (34.31 to 171.54)
Quality of life year	1	(−0.3 (range −0.5 to −0.1))	(−0.2 (−0.3 to −0.1))

^*Probabilities determined directly for the study populations.

^†Probabilities (95% CI).

^‡Determined by using the average nurse's salary with benefits of US$57.18/h × 17 average medication reviews/year × h per review (0.2 h(0.1–1) for automated system and 1.6 h (0.8–5.2) for paper system).

^§The extra nurse's salary required to coordinate management of event.