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Stereo comparison of the binding of hDHFR with Z3 (green) and E4 (cyan) and of mouse DHFR with E1 (violet) in ternary complexes with NADPH. The active-site residues Glu30 and Phe31 are shown. Note that the 2′-methoxyphenyl ring binds in the same orientation in each of these complexes. This figure was drawn with PyMOL (DeLano, 2002 ▶).
