Table 1.
Plasma cytokines 4 h after LPS in mice exposed to MA.
0 mg/kg MA | 5 mg/kg MA | p | |||||
---|---|---|---|---|---|---|---|
Saline | LPS | Saline | LPS | MA | LPS | MA × LPS | |
IL-1β | 124.63 ± 47.25 | 253.4 ± 47.48 | 226.77 ± 10.97 | 135.57 ± 12.7 | 0.82 | 0.59 | 0.0078# |
IL-6 | 36.61 ± 11.41 | 662.74 ± 426.8 | 33.54 ± 9.27 | 1557.7 ± 196.1 | 0.08 | 0.006* | 0.08 |
TNFα | 278.61 ± 78.1 | 501.02 ± 106.5 | 268.05 ± 33.3 | 225.49 ± 32.7 | 0.06 | 0.22 | 0.08 |
IL-10 | 107.89 ± 28.2 | 220.43 ± 33.9 | 111.0 ± 10.57 | 287.12 ± 69.4 | 0.42 | 0.005* | 0.46 |
Mice were given four injections of saline or MA (5 mg/kg) i.p. at 2 h intervals. Twenty-four hours after the first MA injection, mice were given either saline or LPS (100 μg/kg) and blood was collected at 4 h post-injection. *p < 0.01, different from saline controls. #p < 0.01 MA × LPS interaction