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CDK4 and MDM2 analysis. (A) Immunohistochemistry with anti-CDK4 antibody showing strong and quite diffuse nuclear staining of fusiform cells (× 20). (B) Immunohistochemistry with anti-MDM2 antibody showing a more focal nuclear positivity. (C) Fluorescence in situ hybridization of one neoplasic cell: high nuclear amplification of CDK4 (red signals) and MDM2 (green signals), with more than 20 copies (× 40).
